MapDisto features

Efficient software such as Mapmaker or Joinmap have been developed to construct genetic maps from linkage data of experimental segregating populations. However, no option is proposed in these programs to deal with genetic markers which show deviations from expected Mendelian frequencies in their segregation ratios.

Moreover, the use of these programs is not always intuitive and to learn how to deal with their commands can be time-consuming.
MapDisto has tools to :
1) compute and draw genetic maps easily and quickly through a graphical interface,
2) facilitate the analysis of marker data showing segregation distortion due to differential viability of gametes or zygotes.
MapDisto can:
- Find linkage groups, with specified minimum LOD score and maximum recombination frequency,
- Automatically order loci on linkage groups using one of the three available algorithms,
- Compute tables of recombination fractions (various estimates), map distances in centimorgans, linkage and independence khi2s, two-point LOD scores, correlations, for all couples of loci in a sequence, [G-tests for F2 - LODs with SD]
- Compute segregation khi2s that measure the deviation from expected Mendelian segregation and their associated probabilities for all loci of a particular sequence,
- Compute several map parameters for a specified sequence,
- Look for genotyping errors and correct them,
- Draw genetic maps computed either by MapDisto or imported from another program,
- Find QTLs using one-way ANOVA and display a graphical output,
- Export data and run (.in) files for MapMaker/EXP,
- Export computed maps and data for advanced QTL analysis programs such as QTL Cartographer, WinQTLCart, QGene, or MapQTL,
- Run automated commands that make the computation of an entire genetic map very fast and easy,
- Compare maps,
- And many other things.
MapDisto has automated commands that make the computation of an entire genetic map very fast and easy.
The graphical interface permits us to manage data and to navigate into the different output datasheets.
A help that describes MapDisto features and the main steps to follow for data analysis is also available.
The present version of the program handles for several types of segregating populations: backcross (BC1), doubled haploid (DH), single-seed descent (SSD), F2, highly-recombinant inbred lines (HRIL).
A build-in help is included. However, it is very basic. For more help, please read the tutorial.
MapDisto has been developed in Microsoft Visual Basic and needs any Microsoft Excel to run. It works well on Windows and Mac OS X platforms.